Midtown Manhattan, or Midtown, represents the central lengthwise portion of the borough and island of Manhattan in New York City. Midtown is home to some of the city's most iconic buildings, including the Empire State Building, the Chrysler Building, and the headquarters of the United Nations, and it contains world-renowned commercial zones such as Rockefeller Center, Broadway, and Times Square. Along Manhattan's north-south long axis, Midtown Manhattan separates Lower Manhattan from Upper Manhattan.

Midtown Manhattan is the largest central business district in the world and ranks among the most expensive and intensely used pieces of real estate in the world, and Fifth Avenue in Midtown Manhattan commands the world's highest retail rents, at US$3,000 per square foot ($32,000/m²) in 2017.

While Lower Manhattan is the main financial center, Midtown is the country's largest commercial, entertainment, and media center; Midtown Manhattan is also a growing financial center, second in importance in the United States only to Lower Manhattan's Financial District.

The majority of New York City's skyscrapers, including its tallest hotels and apartment towers, lie within Midtown. The area hosts commuters and residents working in its offices, hotels, and retail establishments; many tourists, visiting residents, and students populate the district. 

Times Square, iconic as the world's "heart" and its "Crossroads", is the brightly illuminated hub of the Broadway Theater District, one of the world's busiest pedestrian intersections, and a major center of the world's entertainment industry.